Can stem cells help patients with knee pain after knee replacement

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Many patients still have pain after knee replacement. The common question of course is why? Let’s look for some answers:

This is what a new study from doctors at the New York Hospital for Special Surgery says:

  • “Although total knee replacement is a successful and cost-effective procedure, patient dissatisfaction remains as high as 50%.”1

In the British Medical Journal, doctors at the University of Bristol reported upwards of 34% of patients who had a knee replacement still had knee pain. They concluded: As a large number of people are affected by chronic pain after total knee replacement, care for these patients should be a research priority. 2

In examining why pain persists after knee replacement, doctors at Rush University Medical Center published findings suggesting post-operative knee instability as one of the most common causes of failure of total knee replacements.

  • The instability a can be classified as ligament damage related to intraoperative injuries or excessive release of important coronal stabilizers such as the medial collateral ligament in extension or the posterolateral corner in flexion.3
  • Doctors in Germany agreed: “Ligament instability is a common reason for revision total knee replacement4
  •  While doctors at the University of Iowa also recommend an evaluation of the tendons which may have been damaged during the procedure.

Tendon and ligament damage as cause of pain after knee replacement can be treated with stem cells

To determine if Stem Cell Therapy can be effective in your case, a physical examination is required. Generally Stem Cell Therapy injections could regenerate damaged tissue, supporting the remaining structures of the knee.

1. Park CN, White PB, Meftah M, Ranawat AS, Ranawat CS. Diagnostic Algorithm for Residual Pain After Total Knee Arthroplasty.
Orthopedics. 2016 Mar 1;39(2):e246-52. doi: 10.3928/01477447-20160119-06. Epub 2016 Jan 25.
2 Beswick AD et al.  Interventions for the prediction and management of chronic postsurgical pain after total knee replacement: systematic review of randomised controlled trials. BMJ Open. 2015 May 12;5(5):e007387. doi: 10.1136/bmjopen-2014-007387.
3. Del Gaizo DJ, Della Valle CJ. Instability in primary total knee arthroplasty. Orthopedics. 2011 Sep 9;34(9):e519-21. doi: 10.3928/01477447-20110714-46.
4 Graichen H, Strauch M, Katzhammer T, Zichner L, von Eisenhart-Rothe R. [Ligament instability in total knee arthroplasty – causal analysis.] Orthopade. 2007 Jun 21;
5. Westermann RW, Daniel JW, Callaghan JJ, Amendola A. Arthroscopic Management of Popliteal Tendon Dysfunction in Total Knee Arthroplasty. Arthrosc Tech. 2015 Oct 12;4(5):e565-8. doi: 10.1016/j.eats.2015.06.006. eCollection 2015 Oct.

About Marc Darrow MD, JD

About Marc Darrow MD, JD

Marc Darrow, MD, JD, is one of the leading physicians practicing Stem Cell Therapy, Platelet Rich Plasma Therapy, and Prolotherapy. Email with questions about this article to

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