Marc Darrow MD, JD. Thank you for reading my article. You can ask me your questions about bone marrow derived stem cells using the contact form below. 

We see many post-menopausal women who suffer from significant back and joint pain. Some of these women have had a difficult time in healing because they have, among other health concerns, diminished hormone levels. In this article I am going to look at some of the research that suggests a connection between low-levels of estrogen, osteoarthritic joint pain and osteoporosis. To be clear, supplementation of estrogen can provide a benefit to healing, but estrogen alone, as we will see in the following studies may not be the “one answer,” to joint and back pain. Joint pain and back pain, like hormonal balance, is a complex issue that needs to be thought of in a holistic – whole body or whole joint manner.

Does estrogen supplementation help with joint pain?

A team of investigators from leading American universities, including the University of California at Los Angeles, Stanford University, and the Carver College of Medicine, University of Iowa published a study in the November 2018 issue of the medical journal Menopause, (1) that examined whether or not estrogen supplementation could help with joint pain. Because the use of hormones in helping joint pain is somewhat controversial, meaning that research how shown a mixed bag of results, these investigators focused on estrogen supplementation as a stand alone treatment.

Here are the study highlights and learning points:

  • A total of 10,739 postmenopausal women who have had a hysterectomy were randomized to receive daily oral conjugated equine estrogens (0.625 mg/d) or a matching placebo.
  • The frequency and severity of joint pain and joint swelling were assessed by questionnaire in all participants at entry and on year 1, and in a 9.9% (1/10th of the patients chosen at random) after three years and six years.

RESULTS:

  • At baseline, joint pain and joint swelling were closely comparable in the randomization groups (about 77% with joint pain and 40% with joint swelling).
  • After 1 year, joint pain frequency was significantly lower in the estrogen-alone group compared with the placebo group as was joint pain severity, and the difference in pain between randomization groups persisted through year 3.
  • However, joint swelling frequency was higher in the estrogen-alone group. Adherence-adjusted analyses strengthen estrogen’s association with reduced joint pain but attenuate estrogen’s association with increased joint swelling.

The current findings suggest that estrogen-alone use in postmenopausal women results in a modest but sustained reduction in the frequency of joint pain. But what about the swelling? Was it because of the synthetic estrogen being used? This is where the complexity of hormones comes to play. Look at this study published in the journal Osteoarthritis and Cartilage (2). Here doctors found that women with low serum levels of estradiol, progesterone and testosterone had increased knee swelling-synovitis and possibly other osteoarthritis-related joint degeneration. So inversely, the lack of the estrogen (E2) estradiol was seen as a cause of swelling. Quite the opposite.

So you can see how the use of estrogen supplementation may be considered controversial when it comes to joint pain. However, in many patients, it can be helpful if estrogen is used as part of a regenerative medicine healing program.

Estrogen degenerative disc disease and osteoporosis

In May of 2019, doctors at Southern Medical University, in Guangzhou, China published their paper on the study of the role of estrogen, osteoporosis and degenerative disc disease. What the researchers found controversial was not so much the role of estrogen and back pain, but the role osteoporosis plays in degenerative disc disease. What they wanted to show was that hormones could help with spinal vertebral fractures, and that helping the fractures could help with the the problems of degenerative disc disease.

This was an animal study conducted on female rats. The study’s highlights revealed:

  • Microstructures of C5 vertebral body were weakened significantly after ovariectomy, while restored effectively with estradiol supplementation.
  • Damage to the spinal facet joints led to significant Intervertebral Disc Degeneration because of spinal instability. (Doctors will need to independently address the spinal instability issue).
  • In addition, the estrogen supplement acted as an anti-inflammatory and reduce pain.

The conclusion? Estrogen deficiency exacerbated  Intervertebral Disc Degeneration induced by spinal instability, while estrogen supplementation alleviated the progression of disc degeneration related to osteoporosis.

What does this mean?

Can we help with your joint pain?



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Chlebowski RT, Cirillo DJ, Eaton CB, Stefanick ML, Pettinger M, Carbone LD, Johnson KC, Simon MS, Woods NF, Wactawski-Wende J. Estrogen alone and joint symptoms in the Women’s Health Initiative randomized trial. Menopause. 2018 Nov;25(11):1313-1320.
2.  Jin X, Wang BH, Wang X, Antony B, Zhu Z, Han W, Cicuttini F, Wluka AE, Winzenberg T, Blizzard L, Jones G. Associations between endogenous sex hormones and MRI structural changes in patients with symptomatic knee osteoarthritis. Osteoarthritis and Cartilage. 2017 Feb 2
3. Liu Q, Wang X, Hua Y, Kong G, Wu X, Huang Z, Huang Z, Liu J, Yang Z, Zhu Q. Estrogen Deficiency Exacerbates Intervertebral Disc Degeneration Induced by Spinal Instability in Rats. Spine. 2019 May 1;44(9):E510-9.

There is controversy in the medical community about umbilical cord blood stem cells. Some insist that the injectable solution contains abundant live umbilical cord blood stem cells. Some suggest that the stem cells are not alive. I have seen the flow cytometry showing live stem cells. The research shows that these stem cells release cytokines and growth factors that awaken native stem cells.  I have tried this treatment on myself for both shoulders and knees. After great success, I started using this treatment on patients. I still use PRP and bone marrow depending on the patient’s pathology and requirements. To date the results are excellent for all of these treatments. We are in the process of doing a study on cord blood stem cells (we have done others on bone marrow and PRP) to see which treatments are the most successful. We are awaiting more long term results.