In  recent years doctors have found that by utilizing the growth factors found in the blood (specifically the platelets), a physician can activate stem cells already in the skin to grow new, younger-appearing skin.


  • PRP injections can increase youthful skin thickness and elasticity
  • PRP injections can reduce yellowish skin appearance
  • PRP injections can lessen appearance of wrinkles

There has been a lot of research suggesting how PRP works on damaged skin and wrinkles. A September 2017 study in the Aesthetic surgery journal found that after an injection of PRP (Platelet Rich Plasma, see video below), doctors observed an increase of reticular dermis thickness (the lower of the two layers of the dermis (skin)). This thickening of the skin was due to deposition of elastic fibers (the stuff of skin elasticity) and collagen, with a fibrotic aspect (skin regeneration). (1)

A June 2017 study found that Platelet-rich plasma (PRP) induced a reduction in the manifestations of skin aging, including an improvement in wrinkles and elastosis (yellowish skin). In this research, doctors found that PRP provides growth factors that stimulate fibroblast activation (cells that start collagen production) and induce the synthesis of collagen and other components of the extracellular matrix. (The extracellular matrix is scaffold that collagen builds itself on.)  The study focused on 18 women average age 49 years old. The studies findings include:

  • PRP increased the number of fibroblasts,
  • PRP increased blood vessels in the skin
  • PRP increased collagen density in the skin
  • PRP produced significant improvements in wrinkle and elastosis and photoaging scoring scales. (2)

Published in the Journal of Cosmetic Dermatology, Egyptian physicians say that your own blood platelets can make your face look younger by attacking your wrinkles.

  • In this study 20 patients with different types of facial wrinkles were tested. All subjects received a single PRP intradermal injection and were clinically assessed before and after treatment for a period of 8 weeks using various testing scores including the Wrinkle Severity Rating Scale (WSRS).
  • The most significant results were with younger subjects that have mild and moderate wrinkles of the nasolabial folds.
  • Side effects of PRP treatment were minimal to mild and with excellent tolerability.
  • CONCLUSION: “Single PRP intradermal injection is well tolerated and capable of rejuvenating the face and producing a significant correction of wrinkles especially the NLFs.” (3)

At Cairo University, also publishing in Journal of Cosmetic Dermatology, doctors found that PRP injections yielded significant improvement regarding skin turgor (appearance of plumpness from hydration) and overall vitality. For patients showed positive results for epidermal and dermal thickness.(4)

In Italy, doctors found Platelet Rich Plasma to be an emerging treatment in dermatology for skin rejuvenation. In their study twelve patients underwent 3 sessions of PRP injection at 1-month intervals. Clinical and patient evaluation showed improvement of skin texture. Skin gross elasticity, skin smoothness parameters, skin barrier function, and capacitance were significantly improved.(5)

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1 Charles-de-Sá L, Gontijo-de-Amorim NF, Takiya CM, Borojevic R, Benati D, Bernardi P, Sbarbati A, Rigotti G. Effect of Use of Platelet-Rich Plasma (PRP) in Skin with Intrinsic Aging Process. Aesthetic Surgery Journal. 2017 Sep 7.

2 Cabrera-Ramírez JO, Puebla-Mora AG, González-Ojeda A, García-Martínez D, Cortés-Lares JA, Márquez-Valdés AR, Contreras-Hernández GI, Bracamontes-Blanco J, Ortiz JS, Fuentes-Orozco C. Plasma rico en plaquetas en el tratamiento del fotodaño cutáneo en las manos. Actas Dermo-Sifiliográficas. 2017 Jun 16.

3 Elnehrawy NY, Ibrahim ZA, Eltoukhy AM, Nagy HM. Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. J Cosmet Dermatol. 2017 Mar;16(1):103-111. doi: 10.1111/jocd.12258. Epub 2016 Jul 29.

4 Gawdat HI, Tawdy AM, Hegazy RA, Zakaria MM, Allam RS. Autologous platelet-rich plasma versus readymade  growth factors in skin rejuvenation: A split face study. J Cosmet Dermatol. 2017 Apr 5.

5. Cameli N, Mariano M, Cordone I, Abril E, Masi S, Foddai ML. Autologous Pure Platelet-Rich Plasma Dermal Injections for Facial Skin Rejuvenation: Clinical, Instrumental, and Flow Cytometry Assessment. Dermatol Surg. 2017 Apr 3.