Marc Darrow MD, JD. Thank you for reading my article. You can ask me your questions about  this article using the contact form below. 

In this article we will discuss the aesthetic and facial rejuvenation properties of Platelet Rich Plasma (PRP) Therapy. In our practice we have been using Platelet Rich Plasma Therapy as part of our joint regenerative medicine therapies as well as our aesthetic therapy program for many years. We have been fortunate to help many patients achieve their goals of treatments in both fields.

How does PRP make your face and skin look younger and more vibrant?

PRP treatment addresses:

  • Facial wrinkles
  • Thinning skin
  • Blotchy complexion
  • Dull grey looking skin
  • Loss of skin elasticity/sagging skin

How does it work? 

I will let a June 2019 study in the journal Aesthetic plastic surgery (1) from doctors at the International Society of Aesthetic Plastic Surgery explain:

  • “In recent years, platelet-rich plasma (PRP) has emerged as a promising autologous (from you) biological treatment modality for the use in aesthetic and regenerative medicine. PRP is a high concentration of platelets derived from whole blood which is isolated by centrifugation to separate and concentrate platelet-containing plasma from red blood cells. PRP comprises hundreds of bioactive proteins, including growth factors, peptides, and cytokines (small proteins that initiates cellular repair) that stimulate healing of skin and soft tissues. Attractive features of PRP are the extended release of various growth and differentiation factors from activated platelets, tissue regenerative, and healing capabilities, as well as the lack of problems associated with immunogenicity (the dilution of a drug or chemical substance by your immune system). Because of the unique biological features of this whole blood-derived biological agent, multiple clinical uses for PRP exist for aesthetic and regenerative medicine.
  • PRP treatment has shown itself as a bright future for a safe and efficient cosmetic intervention.”

Simply, your concentrated blood platelets and the healing, growth, and regenerative factors in them rejuvenate your skin.

But it is more than just saying that growth factors are making your skin look good. Here is a list of the know growth factors in PRP Therapy and what they do.I have added explanatory notes:

  • Epidermal Growth Factor (EGF) – Stimulates fibroblasts to secrete collagenase to degrade the matrix during the remodeling phase. Stimulates keratinocyte and fibroblast proliferation.
    • Breaks down dead and dying cells to make room for new cellular growth. Stimulates collagen production.
  • Transforming Growth Factor– Promotes angiogenesis, up-regulates collagen production and inhibits degradation, promotes chemo attraction of inflammatory cells.
    • Helps form new blood vessels which bring blood and “color,” to the skin. Inhibits degradation (the breaksown of collagen and elastins).
  • Vascular Endothelial Growth Factor (VEGF) – Endothelial cells promote angiogenesis during tissue hypoxia.
    • Helps regulate the healing aspects of oxygen in the skin
  • Fibroblast Growth Factor (FGF) – Promotes angiogenesis, granulation, and epithelialization via endothelial cell, fibroblast, and keratinocyte migration, respectively.
    • This complex component of skin rejuvenation can be simply broken down as new blood circulation, inspired by the PRP treatment, is helping to bring the components of healing to repair the damaged skin by getting new healthier skin cells to those areas of damage. Even more simply, FGF is helping to fill in wrinkles and make skin more elastic.
  • Platelet-Derived Growth Factor (PDGF) – Attracts macrophages and fibroblasts to zone of injury. Promotes collagen and proteoglycan synthesis.
    • This growth factor promotes the growth of cells that remove dead tissue and acts as a filler to give skin a more “plump,” apparence.

A recent paper from doctors in Turkey documented these changes and affects. Published in the prestigious medical journal Annals of Dermatology,  the doctors gave only one treatment of PRP. These photos are of patients treated during the study:


Ann Dermatol. 2016 Dec; 28(6): 718–724.

Ann Dermatol. 2016 Dec; 28(6): 718–724. Published online 2016 Nov 23. doi: 10.5021/ad.2016.28.6.718

Every skin product, whether PRP injections, traditional surgical facelift, creams, lotions or other injections such as botox, have before and after pictures. They all show improvements.  But why do we think tPRP therapy is the treatment to offer? Science. PRP has shown long-term to be able to change the skin of the face on a cellular level to that of a more youthful appearance.



Ask about PRP therapy for your skin and face


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