Marc Darrow MD, JD. Thank you for reading my article. You can ask me your questions using the contact form below. 

Before we begin this article, please understand:

Stem cell and PRP injections for musculoskeletal conditions are NOT FDA APPROVED. While research has shown that stem cell and PRP therapy may offer benefits to patients with orthopedic issues, many of these same studies conclude that further evaluation is needed from large, well-controlled clinical trials to verify possible benefits. We only treat orthopedic issues. We do not treat disease. We do not offer IV treatments.

We do not promise stem cell or PRP therapy as a cure for any condition. We provide stem cell and PRP therapy as a same day procedure, without manipulation, stimulation, or culturing of cells. Stem Cell and PRP therapy does not work for everyone. Results achieved by some patients may not be typical for other patients. There are no guarantees that this treatment will help you. All information on this website including reference to current research journals is for educational purposes only. There is controversy in the medical community about whether umbilical cord blood stem cells are alive or dead. You are encouraged to speak with your private medical doctor to help you decide if our treatments might be beneficial for you.

Over the years we have received our fair share of emails from patients seeking treatment for their TMJ. In many of these emails, the sender will describe to us osteoarthritis of the jaw that came as a result of a traumatic injury such as a jaw dislocation during a hockey game or a dislocation or a fractured jaw from an accident. Some will write that their TMJ problems developed when they had some wisdom teeth removed. Others will suggest that TMJ came upon them slowly as a degenerative joint  disease. This article will focus on the later, the connection of degenerative TMJ and degenerative cervical disc disease.

When TMJ is not the result of an acute injury or event

TMJ can develop from a combination of slow moving inter-related factors, sometimes starting with poor head posture that contributes to the stretching and weakening of the cervical neck ligaments and lateral TMJ ligaments. As a result of these degenerative changes, the lower jaw slips forward, aggravating the situation further. Like the people above who had an acute event, people who develop TMJ overtime can also experience loud popping or clicking of bones rubbing together in the loosened joint, accompanied by pain and stiffness as the muscles tighten, trying to compensate for the instigating laxity.

When TMJ makes neck pain worse, when neck pain makes TMJ worse

We see a lot of patients where traditional TMJ treatments such as night appliances, bite guards, pain medications, et al, did not provide relief. The question is why? Sometimes, after an examination of the patient’s head, jaw and neck, we find that many of these patients have a cause and effect relationship where their neck pain and instability is causing and affecting a worsening of their TMJ problems. Their neck is hurting their jaw.

In these patients we find that pain can be traced to soft tissue damage and weakness in the back of the skull, the cervical vertebrae facet joints, the cervical neck ligaments, and the cervical neck muscles.The idea of cervical neck problems causing TMJ problems are not a new idea. In a study published in the journal Clinical Oral Investigations. (1) researchers found that 31 consecutive patients with symptoms of TMJ indicated stability problems at the C0-C3 vertebral levels and tender points in the muscles of the cervical spine.

In 2003 study found that instability in the cervical spine impacted TMJ problems.(2) The researchers of this study found that in many TMJ patients the right and left masticatory muscles were so badly imbalanced that they were causing the cervical spine to become displaced and distorted the patient’s posture.

Why are the cervical neck muscles not more full explored when treating patients with TMJ?

In a November 2018 study in the Canadian journal of physiology and pharmacology(3) doctors questioned why the cervical neck muscles are not more full explored when treating patients with TMJ. The researchers note that disorders or impairments of the masticatory muscles have an obvious effect on how the patient opens and closes their mouth and would therefore account for pain. These researchers point out that the neck muscles may impact negatively on the TMJ muscles and cause further pain and a worsening degenerative condition.

Conventional and non-conventional treatments for TMJ: A comparison of Platelet Rich Plasma injections and other treatments.

PRP treatments involve collecting a small amount of your blood and spinning it in a centrifuge to separate the platelets from the red cells. The collected platelets are then injected back into the jaw and neck are to stimulate healing and regeneration. PRP puts specific components in the blood to work. Blood is made up of four main components; plasma, red blood cells, white blood cells, and platelets. Each part plays a role in injury and degenerative disease healing.

In the first study, doctors at Al-Azhar University, Faculty of Dental Medicine, Cairo in Egypt studied 50 patients with TMJ-osteoarthritis, they found that PRP performed better than hyaluronic acid during long-term follow-up in terms of pain reduction and increased interincisal distance (the ability to open their mouth).(4)

This was a influential study in that it is cited by newer research. Here are some of those studies:

A 2019 study in the International journal of molecular sciences,(5) found that aspiration or arthrocentesis of the jaw joint and platelet-rich plasma injections in temporomandibular disorders’ management were found to be effective in reducing pain and joint sound as well as in improving mandibular motion in a maximum follow-up of 24 months. A 2015 study in the Journal of cranio-maxillofacial surgery concluded that patients suffering from TMJ disc dislocation benefited more from PRP injections than from arthrocentesis to manipulate the jaw back in place. Clearly PRP stabilized the joint and reduced chronic instability.(6)

A 2018 study in the National journal of maxillofacial surgery,(7) researchers compared PRP injections and hydrocortisone with local anesthetic injections in temporomandibular disorders: Here twenty patients with internal derangements of the TMJ were divided in two groups.

  • One group received PRP injection and the other received hydrocortisone with local anaesthetic.
  • In the group of PRP injection, pain was markedly reduced than the group of hydrocortisone with local anesthetic; mouth opening was increased similarly in both groups and TMJ sound was experienced lesser in patients who received PRP.

Doctors from Jagiellonian University, Medical College in Poland (8) found that platelet-rich plasma injections into the temporomandibular joints has a positive impact on the reduction of the intensity of pain experienced by patients treated for temporomandibular joint dysfunction.

Stem cells and TMJ

In the journal Stem Cells International, October 2017, (9) research suggests that Mesenchymal stem cells, derived from the bone marrow play a role as seed cells for the cartilage regeneration of TMJ osteoarthritis. In addition to addressing abnormal remodeling of the subchondral bone (the jaw bone under the TMJ cartilage). The study notes research that has revealed the interaction between chondrocyte (cartilage makers) and adjacent osteoclast or osteoblast (bone makers) to regulate the bone-remodeling process during stem cell repair.

National University of Singapore doctors found that they could regenerate the cartilage of the TMJ joint with a stem cell therapy solution and have recently released their report on stem cell therapy for TMJ and TMD. Here are summary facts on their paper.

  • Temporomandibular Disorders (TMD) represent a group of musculoskeletal and neuromuscular conditions involving the temporomandibular joint (TMJ), masticatory muscles and/or associated structures.
  • They are a major cause of non-dental related face and jaw pain.
  • The most common type of TMJ disorders involves displacement of the TMJ articular disc that precedes progressive degenerative changes of the joint leading to osteoarthritis.

Can any of these treatments help with your TMJ pain?

Generally speaking our treatments can help many people with TMJ symptoms, however, the answer to will it help you?, needs to be determined following a physical examination of your jaw when a realistic assessment can be offered. Treatments do not work for everyone.

Do you have questions? Ask Dr. Darrow

A leading provider of stem cell therapy, platelet rich plasma and prolotherapy

PHONE: (800) 300-9300 or 310-231-7000

There is controversy in the medical community about umbilical cord blood stem cells. Some insist that the injectable solution contains abundant live umbilical cord blood stem cells. Some suggest that the stem cells are not alive. Some research shows that stem cells may release cytokines and growth factors that awaken native stem cells. We also use PRP and bone marrow depending on the patient’s pathology and requirements. We are in the process of doing a large study on cord blood stem cells to ascertain which treatments are the most successful. Short term results show cord blood stems cell and bone marrow concentrate to be statistically equal in efficacy on the scales we record..

1. De Laat A, Meuleman H, Stevens A, Verbeke G. Correlation between cervical spine and temporomandibular disorders. Clinical oral investigations. 1998 Aug 1;2(2):54-7.
2. Shimazaki T, Motoyoshi M, Hosoi K, Namura S. The effect of occlusal alteration and masticatory imbalance on the cervical spine. The European Journal of Orthodontics. 2003 Oct 1;25(5):457-63
3 Fougeront N, Fleiter B. Temporomandibular disorder and comorbid neck pain: facts and hypotheses regarding pain-induced and rehabilitation-induced motor activity changes. Canadian journal of physiology and pharmacology. 2018 Aug 1;96(11):1051-9.
4 Hegab AF et al. Platelet-Rich Plasma Injection as an Effective Treatment for Temporomandibular Joint Osteoarthritis. J Oral Maxillofac Surg. 2015 Sep;73(9):1706-13. doi: 10.1016/j.joms.2015.03.045. Epub 2015 Mar 24.
5 Zotti, F., Albanese, M., Rodella, L. F., & Nocini, P. F. (2019). Platelet-Rich Plasma in Treatment of Temporomandibular Joint Dysfunctions: Narrative Review. International journal of molecular sciences20(2), 277. doi:10.3390/ijms20020277
6 Gupta S, Sharma AK, Purohit J, Goyal R, Malviya Y, Jain S. Comparison between intra-articular platelet-rich plasma injection versus hydrocortisone with local anesthetic injections in temporomandibular disorders: A double-blind study. Natl J Maxillofac Surg. 2018;9(2):205-208.
7. Hancı M, Karamese M, Tosun Z, Aktan TM, Duman S, Savaci N. Intra-articular platelet-rich plasma injection for the treatment of temporomandibular disorders and a comparison with arthrocentesis. J Craniomaxillofac Surg. 2015 Jan;43(1):162-6. doi: 10.1016/j.jcms.2014.11.002. Epub 2014 Nov 15.
8 Pihut M, Szuta M, Ferendiuk E, Zeńczak-Więckiewicz D. Evaluation of pain regression in patients with temporomandibular dysfunction treated by intra-articular platelet-rich plasma injections: a preliminary report. Biomed Res Int. 2014;2014:132369. doi: 10.1155/2014/132369. Epub 2014 Aug 3.
9 Cui D, Li H, Xu X, Ye L, Zhou X, Zheng L, Zhou Y. Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis. Stem Cells International. 2017;2017.