Stem cell therapy can repair the damage of bone-on-bone knees

 

Stem cells are present in normal cartilage and act as constant repairing agents. In fact, in osteoarthritic knees, stem cells are seen in larger numbers in recognition that degenerative disease is occurring.

 

However, despite their larger numbers, the native stem cells act chaotically and are unable to regroup themselves into a healing mechanism and repair the bone, cartilage and other tissue. Introducing bone marrow stem cells into this environment gets the native stem cells in line and redirects them to perform healing functions. The joint environment is changed from chaotic to healing

Read: Stem cell therapy can repair the damage of bone-on-bone knees


 

Stem Cells and PRP options to hip replacement

 

A team of European researchers are suggesting in the medical journal BMC Health Services Research that patients be allowed to make informed choices about hip osteoarthritis treatments including the need for hip replacement: “Patients with hip osteoarthritis are in great need of information both at the time of diagnosis and further throughout the disease development and care continuum.

 

Lack of information may result in unnecessary and dysfunctional misconceptions, underuse of potentially helpful treatment options and uninformed decisions. Patients need continuous support from health professionals and their families in order to find and consider effective treatment strategies.”

Read: Stem Cells and PRP options to hip replacement


 

Fat stem cells or bone marrow stem cells?

 

If you are suffering from osteoarthritic pain and are researching alternatives to joint replacement or for help in relieving continued pain after joint replacement you will come upon information comparing the use of bone marrow derived stem cells and adipose or fat derived stem cells in aiding your situation.

 

In my office I choose to use bone marrow-derived stem cells because I find that we can achieve the patient’s goals of treatment using this approach. What we are looking to do is achieve both the patient’s expectations and the goals of the treatment of Stem Cell Therapy, which can be accomplished best and simply by harnessing bone marrow stem cells.

Read: Fat stem cells or bone marrow stem cells?


 

How stem cells make natural hyaluronic acid

 

Hyaluronic acid is a naturally occurring substance that is a major component of the protective synovial fluid that surrounds the knee. In its natural form it is also a key component of wound healing. In its processed form used for injection purposes, hyaluronic acid is NOT a key healing component as attested to by suggestions and recommendations that these injections are stop gaps until knee replacement can be performed.

Read: How stem cells make natural hyaluronic acid


 

Stem Cells for Knees: Promising Treatment or Hoax?

This is a webmd.com article featuring Marc Darrow, MD, JD:

April 14, 2017 — At 55, George Chung of Los Angeles could keep up with skiers decades younger, taking on difficult slopes for hours and hours. “Skiing was my passion,” he says.

 

Then the pain started, and the bad news. He had severe osteoarthritis, the ”wear-and-tear” type, in both knees. Doctors suggested surgery, but he chose instead an investigational treatment — injections of stem cells. Two months after the first treatment, he was out of pain. “I had been in pain of various degrees for 6 years,” he says.

 

Now, nine treatments and 3 years later, he is back to intense skiing. Last year, he also took up long-distance cycling, completed five double-century cycling rides, and earned the prestigious California Triple Crown cycling award.

Read: Stem Cells for Knees: Promising Treatment or Hoax?


 

Biological Knee Reconstruction without surgery – Using Stem Cells

 

The definition of osteochondral is that it is related to the cartilage and bone. In the knee joint cartilage protects the shin bone, the thighbone, and the back of the knee cap – the patella. A healthy knee has all its surfaces glide smoothly atop these cartilages for pain free, efficient, and in the case of athletics – explosive movement. In recent research investigators suggested that stem cell therapy could provide the answer where drug interventions and surgical procedures were lacking:

Read: Biological Knee Reconstruction without surgery – Using Stem Cells


 

Stem cells for knee osteoarthritis in the active sports-minded patient

 

In the January 2017 edition of the American Journal of Sports Medicine, doctors at the Mayo Clinic have released a new study on the effectiveness of bone marrow derived stem cells for knee osteoarthritis in the active patient. In this prospective, single-blind, placebo-controlled trial, 25 patients with pain in both knees from osteoarthritis were randomized to receive bone marrow derived stem cells into one knee and saline placebo into the other.

Read: Stem cells for knee osteoarthritis in the active sports-minded patient


 

Can stem cells regenerate missing meniscus tissue?

 

Doctors at Tokyo Medical and Dental University are tackling the problem of regenerating missing meniscus tissue.

 

In their research they examined the process of meniscal regeneration and cartilage degeneration following meniscus surgical removal in mice. They found that there is a healing environment that the meniscus and cartilage create independently of each other spurred on by native stem cells, that later melds together, suggestive of a balance between meniscal regeneration and cartilage homeostasis. The meniscus and cartilage are trying to regenerate each other.

Read: Stem cell therapy can repair meniscus damage 


 

Stem cells for herniated discs

 

I have written many articles on stem cell therapy and how they change the degenerative disease environment of the inner spine to a healing environment.

 

When stem cells are injected into the spine or joint they initially set up a line of communication with the immune system and begin exchanging messages. The stem cells tell the immune cells to call healing factors to the site of damage and to meet them at the points where repair is needed. This is when healing begins.

 

A recent paper from Australian researchers explains how this change of environment works.

Read: Stem cells for herniated discs


 

Rotator cuff stem cell treatments

 

Research surrounding how stem cells repair rotator cuff tears Doctors at various Chinese medical universities combined to publish new research on the need for alternatives to rotator cuff surgery.  Enhancing cellular communication may be the answer.

 

“Rotator cuff tears are one of the most common shoulder problems that usually require operative treatments. Therapeutic options used to repair ruptured tendons have consisted of suture, autografts, allografts (transplants), and synthetic prostheses.

 

Although surgical treatments have improved dramatically up to now, shoulder pathology is still challenging to orthopedic surgery primarily because these injuries often respond poorly to treatment and require prolonged rehabilitation.

Read: Research surrounding how stem cells repair rotator cuff tears


 

Stem Cells for sports rehab

 

“Cell-based therapies and regenerative medicine offer safe and potentially efficacious treatment for sports-related musculoskeletal injuries. Basic science and preclinical studies that support the possibility of enhanced recovery from sports injuries using cell-based therapies are accumulating; however, more clinical evidence is necessary to define the indications and parameters for their use.”1 That was written in 2014 in the Orthopaedic journal of sports medicine.

Read stem cells for sports rehab

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1. Yang J, Sun Y, Xu P, Cheng B.Can patients get better clinical outcomes by using PRP in rotator cuff repair: a meta-analysis of randomized controlled trials. J Sports Med Phys Fitness. 2015 Oct 16. [Epub ahead of print]

2. Rafols C, Monckeberg JE, Numair J, Botello J, Rosales J. Platelet-Rich Plasma Augmentation of Arthroscopic Hip Surgery for Femoroacetabular Impingement: A Prospective Study With 24-Month Follow-up. Arthroscopy. 2015 Oct;31(10):1886-92. doi: 10.1016/j.arthro.2015.03.025. Epub 2015 May 15.

3. Hoffman JK, Protzman NM, Malhotra AD. Biologic Augmentation of the Ulnar Collateral Ligament in the Elbow of a Professional Baseball Pitcher. Case Rep Orthop. 2015;2015:130157. doi: 10.1155/2015/130157. Epub 2015 Jul 9.

4. Dargel J, Boomkamp E, Wegmann K, Eysel P, Müller LP, Hackl M. Reconstruction of the lateral ulnar collateral ligament of the elbow: a comparative biomechanical study. Knee Surg Sports Traumatol Arthrosc. 2015 May 10. [Epub ahead of print]

5.  Salamanna F, Veronesi F. New and Emerging Strategies in Platelet-Rich Plasma Application in Musculoskeletal Regenerative Procedures: General Overview on Still Open Questions and Outlook. BioMed Research International. Volume 2015 (2015), Article ID 846045, 24 pages

6. Oryan A, Alidadi S, Moshiri A Platelet-rich plasma for bone healing and regeneration. Expert Opin Biol Ther. 2015 Dec 4:1-20. [Epub ahead of print]

7. Mattiello A, Cacciapuoti C. Autologous Platelet Gel Improves Bone Reconstruction of Large Defects in Patients with Bone Giant Cell Tumors. In Vivo. 2015 09-10;29(5):533-540.

8. Civinini R, Nistri L, Martini C, Redl B, Ristori G, Innocenti M. Growth factors in the treatment of early osteoarthritis. Clin Cases Miner Bone Metab. 2013 Jan;10(1):26-9. doi: 10.11138/ccmbm/2013.10.1.026. PUBMED ABSTRACT

9. Dallari D, Stagni C, Rani N, Sabbioni G, Pelotti P, Torricelli P, Tschon M, Giavaresi G. Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled Study. Am J Sports Med. 2016 Jan 21. pii: 0363546515620383. [Epub ahead of print]

10. Gullung GB1, Woodall JW, Tucci MA, James J, Black DA, McGuire RA. Platelet-rich plasma effects on degenerative disc disease: analysis of histology and imaging in an animal model. Evid Based Spine Care J. 2011 Nov;2(4):13-8. doi: 10.1055/s-0031-1274752.

11. Khalaf K, Nikkhoo M, Ya-Wen Kuo, Yu-Chun Hsu, Parnianpour M, Campbell-Kyureghyan N, Haghpanahi M, Jaw-Lin Wang. Recovering the mechanical properties of denatured intervertebral discs through Platelet-Rich Plasma therapy. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:933-6. doi: 10.1109/EMBC.2015.7318516.

12. Kanchanatawan W et al. Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2015 Sep 19. [Epub ahead of print]

13. Pourcho AM, Smith J, Wisniewski SJ, Sellon JL.Intraarticular platelet-rich plasma injection in the treatment of knee osteoarthritis: review and recommendations. Am J Phys Med Rehabil. 2014 Nov;93(11 Suppl 3):S108-21. doi: 10.1097/PHM.0000000000000115.

14. Li M, Zhang C, Ai Z, Yuan T, Feng Y, Jia W. Therapeutic effectiveness of intra-knee-articular injection of platelet-rich plasma on knee articular cartilage degeneration. Li M, Zhang C, Ai Z, Yuan T, Feng Y, Jia W.

15. Wang-Saegusa A, Cugat R, Ares O, et al. Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop Trauma Surg. 2011 Mar;131(3):311-7. Epub 2010 Aug 17.

16. Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study. Sampson S, Reed M, Silvers H, et al. Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study.Am J Phys Med Rehabil. 2010 Dec;89(12):961-9.

17. Blanke F, Vavken P, Haenle M, von Wehren L, Pagenstert G, Majewski M. Percutaneous injections of Platelet rich plasma for treatment of intrasubstance meniscal lesions. Muscles Ligaments Tendons J. 2015 Oct 20;5(3):162-166.

18. Campbell KA, Saltzman BM, Mascarenhas R, Khair MM, Verma NN, Bach BR Jr, Cole BJ. A Systematic Review of Overlapping Meta-analyses. Arthroscopy. 2015 Nov;31(11):2213-21. doi: 10.1016/j.arthro.2015.03.041. Epub 2015 May 29.

19. Wu CC, Chen WH, Zao B, Lai PL, Lin TC, Lo HY, Shieh YH, Wu CH, Deng WP. Regenerative potentials of platelet-rich plasma enhanced by collagen in retrieving pro-inflammatory cytokine-inhibited chondrogenesis. Biomaterials. 2011 Sep;32(25):5847-54. Epub 2011 May 25.

20. van Buul GM, et al. Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes. Am J Sports Med. 2011 Nov;39(11):2362-70. Epub 2011 Aug 19.

21. Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, Canacchi A, Fornasari PM, Giannini S, Marcacci M. Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 2010; 18(4):472-479.

22. Gosens T, Den Oudsten BL, Fievez E, van ‘t Spijker P, Fievez A. Pain and activity levels before and after platelet-rich plasma injection treatment of patellar tendinopathy: a prospective cohort study and the influence of previous treatments.Int Orthop. 2012 Apr 27. [Epub ahead of print]

23. von Wehren L1, Blanke F, Todorov A, Heisterbach P, Sailer J, Majewski M. The effect of subacromial injections of autologous conditioned plasma versus cortisone for the treatment of symptomatic partial rotator cuff tears. Knee Surg Sports Traumatol Arthrosc. 2015 May 28. [Epub ahead of print]

24. Valencia Mora M, Ruiz Ibán MA, Díaz Heredia J, Barco Laakso R, Cuéllar R1, García Arranz M. Stem cell therapy in the management of shoulder rotator cuff disorders. World J Stem Cells. 2015 May 26;7(4):691-9. doi: 10.4252/wjsc.v7.i4.691.

25. Guelfi M, Pantalone A, Vanni D, Abate M, et al. Long-term beneficial effects of platelet-rich plasma for non-insertional Achilles tendinopathy. Foot Ankle Surg. 2015 Sep;21(3):178-81. doi: 10.1016/j.fas.2014.11.005. Epub 2014 Dec 11. PUBMED ABSTRACT

26. López-Gavito E, Gómez-Carlín LA, Parra-Téllez P, Vázquez-Escamilla J. Platelet-rich plasma for managing calcaneus tendon tendinopathy and plantar fasciitis. Acta Ortop Mex. 2011 Nov-Dec;25(6):380-5. PUBMED PRP ABSTRACT

27. Gaweda K, Tarczynska M, Krzyzanowski W. Treatment of Achilles tendinopathy with platelet-rich plasma. Int J Sports Med. 2010 Aug;31(8):577-83. Epub 2010 Jun 9. PUBMED ABSTRCAT